Tide Motion Bioreactor TideCell

The Esco TideCell® Bioreactor System is the world’s largest linearly scalable single-use bioreactor, from seed preparation to 5000 liters with closed automated cell harvesting. It is the pilot/production scale system of Esco VacciXcell’s Tide Motion Bioreactors.

One of the main advantages of Esco VacciXcell’s Tide Motion Bioreactor system is that it features the same bioprocess method from seed preparation to production scale. This is essential as certain cell lines do not grow well when seed preparation is done in 2D culture then cultured in 3D.

Esco VacciXcell's Tide Motion System is the highest yield and lowest cost packed bed bioreactor and the only packed bed bioreactor that can be placed inside a cGMP isolator, which can then be placed in Grade C-D environment, making it an ideal system for the production of wild-type viruses. This feature reduces the costs of cleanrooms by decreasing the requirements for Personnel Protective Equipment (PPE), Utilities, and Viable/Non-Viable monitoring and eliminating gowning airlocks, which are needed in larger Grade A and B cleanrooms.

Features :

• Linearly scalable up to 5000L
• High productivity: TideCell®-100 equivalent to 20,000 roller bottles
• Large surface area
• No bubbling and foaming due to separate matrix vessels and mixing vessels
• Low shear stress reducing cell debris
• Lower downstream bioprocessing costs:
• Lower cell debris in harvest medium
• Much lower for secreted products, as cell remain entrapped within the carriers
• No oxygen limitation due to dual oxygenation scheme
• Closed system cell harvest and seed transfer

Applications

• Pilot/Production scale culture of anchorage-dependent cells
• Switching from roller bottles to a closed system
• Vaccine production
• Allogeneic Cell Therapy
• Biosimilars and Biobetters production
• Cell Mass Train